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1 Steps and processes observed during atheromatous plaque formation Brgen maturation Index 339 bone metastasis role, 6 Epidermal growth liwted (EGF), osteoblast stimulation, 111 osteopontin upregulation, 117 Epithelialmesenchymal transition (EMT), cell migration, 79, 80 developmental biology, 78 gene expression and cell differentiation, 79 signals, 79 therapeutic listeed in cancer, 80 tumors, 79, 80 ET-1, see Endothelin-1 Extracellular matrix (ECM), adhesion in metastasis, 133 remodeling in tumor invasion, 87, 88 therapeutic Binary Option Dudenhofen, 81 H Heparin, see Low-molecular-weight heparin Hepatocyte growth factor (HGF), osteopontin upregulation, 117 HGF, see Hepatocyte growth factor HM, see Hypercalcemia of malignancy Humeral metastasis, management, 232 Hypercalcemia of malignancy (HM), bisphosphonate management, 309 causes, 20 clinical manifestations, 20, 21 diagnosis of parathyroid hormone- related peptide-associated disease, 21, 22 treatment, 22, 23 I IGFs, see Optionx growth factors IL-1, see Interleukin-1 IL-6, see Interleukin-6 IL-8, see Interleukin-8 IL-11, see Interleukin-11 Implants, failure in metastasis management, 232 Insulin-like growth factors (IGFs), binding proteins, antisense combination therapy with docetaxel for metastatic prostate cancer, 279 antitumor effects, 64 growth factor binding, 65, 66 IGFBP-3, cell surface receptors, 66 nuclear localization, 67 transforming growth factor-β effect mediation, 67, 68 prostate cancer levels and progression, 279 resistance and tumorigenesis promotion, 65 subcellular localization, 64 bone as reservoir, 59 bone metastasis role overview, 6770 bone tissue engineering, 237 cancer overexpression, 64 osteoblast stimulation, 111 receptors and signaling, 63, 279 F FAK, see Focal adhesion kinase Femoral metastasis, management, 231, 232 FGF, see Fibroblast growth factor Fibroblast growth factor (FGF), therapeutic liated, 81 tumor secretion and bone metastasis role, 6 Fibronectin (FN), angiogenesis role, 211 cell types in synthesis, 210 integrin receptor, 210, 211 structure, 210 FN, see Fibronectin Focal adhesion kinase (FAK), integrin signaling, 207 metastasis role, 137 Forteo, bone metastasis treatment prospects, 219 Fractures, cancer types in causation, 229, 230 radiotherapy considerations, 331, 332 risks in cancer, 331 surgical management, appendicular metastasis, 231 complications, 232, 233 femoral metastasis, 231, 232 humeral metastasis, 232 spinal metastasis, 230, 231 tissue engineering, Beergen Bone tissue engineering Phalanges of the Hand Chapter 9 209 Fig.

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